in the News
Gut check on cancer
Cracking the mysteries of the human microbiome—those teeming communities of bacteria, fungi, and viruses that live on and within each of us—remains one of medicine’s most exciting frontiers.
CFI's Alex Khoruts is quoted by NBC News
As the number of transplants increased so did the methods of delivery. Today the debate is whether or not to designate the FMT as an investigational drug or to continue with the FMTs as organ transplants.
Drug Companies and Doctors Battle Over the Future of Fecal Transplants
There’s a new war raging in health care, with hundreds of millions of dollars at stake and thousands of lives in the balance.
Mysteries of the Microbiome
Dr. Alexander Khoruts understands if you hesitate to shake his hand. He does dirty work. But he’s saving lives with what the rest of us flush away.
There were no guidelines for fecal transplants. Then, a patient died.
In June, after a patient died and another was sickened from a fecal transplant that contained drug-resistant bacteria, the Food and Drug Administration stepped in and set new guidelines for the procedure.
A clinician's guide to microbiome testing
The intestinal microbiota, also commonly known as the ‘‘gut microbiome’’ is integral to human physiology and has wide-ranging effects on the development and function of the immune system, energy metabolism and even nervous system activity.
Patient-turned-researcher teams up with her doctor to advance U of M’s pioneering microbiota transplant program.
How sun exposure can affect your microbiome
On the surface, sunlight and gut microbes seem to have nothing in common — after all, your gut bacteria are unlikely to find themselves catching some rays.
Fecal transplants work better than antibiotics to treat deadly bacterial infection
The new study is the first to look at the treatment’s effects on complications that can stem from the infection.
Fecal Microbiota Transplantation: An Interview with Alex Khoruts
A new, highly active sector of therapeutics in the form of fecal microbiota transplantation (FMT) has emerged in the last several years based on novel paradigms in medicine that are challenging to the regulators such as the US Food and Drug Administration (FDA).
Minnesota faces challenge in halting deadly colon infection's spread
For years, a bacteria known as Clostridium difficile that can cause intestinal infections, crippling diarrhea and even death was thought to be a problem confined to hospitals and care facilities.
FDA hears testimony on enforcement discretion of FMT for C. diff
The FDA held a public comment session on Monday in Washington, D.C., to hear testimony on the agency’s policy on enforcement discretion of fecal microbiota transplantation for patients with recurrent Clostridioides difficile infection, as well as what is needed to make a path forward to approval.
How Microbes Defend and Define Us
Dr. Alexander Khoruts had run out of options. In 2008, Dr. Khoruts, a gastroenterologist at the University of Minnesota, took on a patient suffering from a vicious gut infection of Clostridium difficile.
Minnesota researchers help unlock 'gut science' cures
The Twin Cities is emerging as a major player in what could become a multibillion dollar industry: Gut science.
Excerpt from Gulp: Adventure on the Alimentary Canal by Mary Roach
It’s tough to find an inappropriate mealtime conversation with this group – not because they’re crass or ill-mannered, but because they view the universe of the colon very differently from the rest of us.
Online Video of Evolving Human Microbiome Lecture Now Available
On February 17, Alexander Khoruts, MD, of the University of Minnesota’s Microbiota Therapeutics Program delivered the first lecture in the three-part Consortium-sponsored microbiome series.
Fecal Microbiota Transplantation Is Poised for a Makeover
With multiple therapeutics in the pipeline for recurrent Clostridium difficile infection, clinicians foresee a shift in treatment options for the condition.
Can patients' gut microbes help fight cancer?
At first glance, it might seem odd that our gut microbiome plays an influential role in our immune system response. It’s not so strange, though, considering that the vast majority of our immune cells, up to 70%–80% of them, hang out in the intestine regularly.