Program History

Our First FMT

August 21, 2008

Our first FMT was completed by Dr. Khoruts The donor was the patient’s husband. Click here to find the case report describing this patient, which contained the first documentation of engraftment of donor microbiota. Published in May 2010 in the Journal of Clinical Gastroenterology

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Microbiota Engraftment

December 1, 2011

Demonstration of microbiota engraftment was central to the new terminology of what was formerly known by various names, e.g., fecal bacteriotherapy, to ‘Fecal Microbiota Transplantation’. The term was first used in a December 2011 publication link: Clinical Gastroenterology and Hepatology2011;9:1044–1049

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Development of GMP Protocols

January 1, 2012

Development of GMP protocols began at MCT. Our program was working in collaboration with a start-up company called NuQure, which later became CIPAC, then Crestovo, and ultimately Finch Therapeutics.

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FDA Hearing

May 1, 2013

On this day, the FDA workshop classified FMT as a drug and a biologic.

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Enforcement Discretion Policy

July 1, 2013

The FDA announced the enforcement discretion policy with respect regulation of FMT. This policy allows physicians use of FMT in treatment of C. difficile infections that do not respond to standard therapies without federal regulatory oversight.

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Treatment of fulminant C. difficile infection

September 1, 2013

The FMT protocol for treatment of fulminant C. difficile infection was published in the Journal of Clinical Gastroenterology in September of 2013.

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1st Capsule Treatment

January 15, 2015

1st Capsule Treatment

The first treatment with capsule preparation of freeze-dried microbiota was done in January 2015.

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July 7, 2019

We renamed the treatment of FMT to IMT Intestinal Microbiota Transplantation’, published in the American Journal of Gastroenterology in 2019. Click here.

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